Sarsaparilla - Don’t Do Like the Smurfs! In the comic strip, the Smurfs adore eating sarsaparilla. Humans beware - only the roots and the leaves may be consumed (for their therapeutic effect). The fruit, tiny red berries are highly toxic. Smilax aspera by David Gaya Now I Know 818 I Knew it 391 You Might Also Like Write a comment... awesome comments!